Friday, August 5, 2011

statistical geneticist 8/5/2011

Statistical geneticist, human whole genome sequence analysis
Knome, Inc. is a trail-blazing human genome sequence interpretation
company based in Cambridge, MA.  Founded by George Church, Knome
analyzes human whole genomes and exomes for researchers probing the
genetic basis of health.

We seek a self-starter with doctoral training in statistical genetics,

to join a team building new tools to efficiently glean insight from
human genomes.  Applicant must have deep expertise in genetics and
associated statistical methods; experience with analytic and heuristic
methods for finding complex genotype-phenotype associations; and
fluency in R, Octave, C++, Perl, Python, and/or other relevant coding
environments.  Understanding of human genetic and phenotypic
variation, and/or clinical, population, or evolutionary genetics is
ideal.  And direct experience with high-throughput genome sequence
data is preferred.  Above all, applicant must be passionately
interested in the fast-emerging utility of whole genome comparative
analysis in basic and clinical research.

Responsibilities may include:
•     Devising new algorithms (and adapting existing methods) for
comparing whole human genome sequences, to efficiently find candidate
health-relevant variants, genes, and pathways
•     Working with software developers to integrate new methods into
Knome’s automated genome analysis engine
•     Analyzing live data sets, in order to catalyze discoveries
•     Publishing relevant research findings and innovative methods
•     Tracking developments in statistical genetics through peer-reviewed
literature, blogs, webcasts, conference proceedings, and communication
with other field leaders

Desired skills:
•     Cross-disciplinary academic or professional training in statistical
genetics, computer science, and/or human genetics
•     Top-notch problem-solving skills
•     Comfort in relevant statistical and bioinformatics scripting and
programming environments
•     Familiarity with relevant toolkits and databases (e.g.,
BioConductor, 1000genomes, KEGG, ENSEMBL)
•     Ability to work both independently and as part of an entrepreneurial


Knome’s Reward Package is made up of three parts, as follows:
• Base Compensation
• Stock Option Grants for all full-time employees
• Benefits

Knome offers its eligible employees a comprehensive and competitive
benefits package. Knome contributes to the benefits package.
• Medical Coverage
• Dental Coverage
• Flexible Spending Accounts (FSA)
• Long-term Disability Insurance
• Life and AD&D Insurance
• Employee Assistance Program
• 401(k) Retirement Plan
• 15 vacation days and 9 holidays per year
• Direct Deposit

This benefits-at-a-glance has been designed to give you an overview of
the Knome Reward Package. It does not, however, attempt to explain all
the details, provisions, restrictions and exclusions of the package.
The Company reserves the right to change or terminate any part of this
package at any time.

Compensation will be commensurate with experience, with opportunities
for an equity stake in an early-stage company.  This is a full-time
job, located in Cambridge, MA.

Qualified candidates: please contact with your
resume and cover letter.

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